A Straightforward Stereoselective Synthesis ofd- andl-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine
نویسندگان
چکیده
منابع مشابه
A straightforward stereoselective synthesis of D- and L-5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine.
A novel and facile synthesis of 5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine 1 is described. The key steps involve a Diels-Alder reaction of ethyl (2E)-3-acetyloxy-2-propenoate 2 as dienophile with Danishefsky's diene 3 to build up the six-membered ring skeleton, a Fraser-Reid reductive rearrangement of the adduct using LiAlH(4), and base-moiety introduction using a Mitsunobu reaction. Optic...
متن کاملA Straightforward Stereoselective Synthesis of D-and L-5-hydroxy-4-hydroxymethyl-2- Cyclohexenylguanine Original Citation a Straightforward Stereoselective Synthesis of D-and L-5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2001
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo015924z